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Making insulin-deficient type 1 diabetic rodents thrive without insulin

Terminally ill insulin-deficient rodents with uncontrolled diabetes due to autoimmune or chemical destruction of β-cells were made hyperleptinemic by adenoviral transfer of the leptin gene. Within ≈10 days their severe hyperglycemia and ketosis were corrected. Despite the lack of insulin, moribund a...

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Bibliografische gegevens
Hoofdauteurs: Yu, Xinxin, Park, Byung-Hyun, Wang, May-Yun, Wang, Zhao V., Unger, Roger H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544580/
https://ncbi.nlm.nih.gov/pubmed/18779578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806993105
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