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Molecular basis for LDL receptor recognition by PCSK9

Proprotein convertase subtilisin/kexin type 9 (PCSK9) posttranslationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kwon, Hyock Joo, Lagace, Thomas A., McNutt, Markey C., Horton, Jay D., Deisenhofer, Johann
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538846/
https://ncbi.nlm.nih.gov/pubmed/18250299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712064105
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