Wird geladen...

Plasma PCSK9 preferentially reduces liver LDL receptors in mice

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates the expression of LDL receptor (LDLR) protein. Gain-of-function mutations in PCSK9 cause hypercholesterolemia, and loss-of-function mutations result in lower plasma LDL-cholesterol. Here, we investigate the ki...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Grefhorst, Aldo, McNutt, Markey C., Lagace, Thomas A., Horton, Jay D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386900/
https://ncbi.nlm.nih.gov/pubmed/18354138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800027-JLR200
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!