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Plasma PCSK9 preferentially reduces liver LDL receptors in mice
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates the expression of LDL receptor (LDLR) protein. Gain-of-function mutations in PCSK9 cause hypercholesterolemia, and loss-of-function mutations result in lower plasma LDL-cholesterol. Here, we investigate the ki...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2386900/ https://ncbi.nlm.nih.gov/pubmed/18354138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M800027-JLR200 |
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