Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proteinase K subfamily of subtilases that reduces the number of LDL receptors (LDLRs) in liver through an undefined posttranscriptional mechanism. We show that purified PCSK9 added to the medium of HepG2 cells reduces the numbe...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lagace, Thomas A., Curtis, David E., Garuti, Rita, McNutt, Markey C., Park, Sahng Wook, Prather, Heidi B., Anderson, Norma N., Ho, Y.K., Hammer, Robert E., Horton, Jay D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1626117/
https://ncbi.nlm.nih.gov/pubmed/17080197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29383
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados