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PCSK9: a convertase that coordinates LDL catabolism

The identification and characterization of proprotein convertase subtilisin-like/kexin type 9 (PCSK9) have provided new insights into LDL metabolism and the causal role of LDL in coronary heart disease (CHD). PCSK9 is a secreted protease that mediates degradation of the LDL receptor by interacting w...

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Detalhes bibliográficos
Main Authors: Horton, Jay D., Cohen, Jonathan C., Hobbs, Helen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674748/
https://ncbi.nlm.nih.gov/pubmed/19020338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.R800091-JLR200
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