PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells

Por Lagace, Thomas A.
Publicado em 2014

Phosphatidylcholine: Greasing the Cholesterol Transport Machinery

Por Lagace, Thomas A.
Publicado no Lipid Insights (2016)

The Rate-limiting Enzyme in Phosphatidylcholine Synthesis Regulates Proliferation of the Nucleoplasmic Reticulum

Por Lagace, Thomas A., Ridgway, Neale D.
Publicado em 2005

Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms.

Por Ridgway, Neale D, Lagace, Thomas A
Publicado em 2003

Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase α (CCTα)

Por Lagace, Thomas A., Ridgway, Neale D.
Publicado em 2005

Internalized PCSK9 dissociates from recycling LDL receptors in PCSK9-resistant SV-589 fibroblasts

Por Nguyen, My-Anh, Kosenko, Tanja, Lagace, Thomas A.
Publicado em 2014

Caspase Processing and Nuclear Export of CTP:Phosphocholine Cytidylyltransferase α during Farnesol-Induced Apoptosis

Por Lagace, Thomas A., Miller, Jessica R., Ridgway, Neale D.
Publicado em 2002

Low Density Lipoprotein Binds to Proprotein Convertase Subtilisin/Kexin Type-9 (PCSK9) in Human Plasma and Inhibits PCSK9-mediated Low Density Lipoprotein Receptor Degradation

Por Kosenko, Tanja, Golder, Mia, Leblond, Geoffrey, Weng, Willy, Lagace, Thomas A.
Publicado em 2013

Plasma PCSK9 preferentially reduces liver LDL receptors in mice

Por Grefhorst, Aldo, McNutt, Markey C., Lagace, Thomas A., Horton, Jay D.
Publicado em 2008

Phosphatidylcholine Synthesis Influences the Diacylglycerol Homeostasis Required for Sec14p-dependent Golgi Function and Cell Growth

Por Henneberry, Annette L., Lagace, Thomas A., Ridgway, Neale D., McMaster, Christopher R.
Publicado em 2001

Molecular basis for LDL receptor recognition by PCSK9

Por Kwon, Hyock Joo, Lagace, Thomas A., McNutt, Markey C., Horton, Jay D., Deisenhofer, Johann
Publicado em 2008

Genetic and Metabolic Determinants of Plasma PCSK9 Levels

Por Lakoski, Susan G., Lagace, Thomas A., Cohen, Jonathan C., Horton, Jay D., Hobbs, Helen H.
Publicado em 2009

Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

Por McNutt, Markey C., Kwon, Hyock Joo, Chen, Chiyuan, Chen, Justin R., Horton, Jay D., Lagace, Thomas A.
Publicado em 2009

Molecular Characterization of Loss-of-Function Mutations in PCSK9 and Identification of a Compound Heterozygote

Por Zhao, Zhenze, Tuakli-Wosornu, Yetsa, Lagace, Thomas A., Kinch, Lisa, Grishin, Nicholas V., Horton, Jay D., Cohen, Jonathan C., Hobbs, Helen H.
Publicado em 2006

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice

Por Lagace, Thomas A., Curtis, David E., Garuti, Rita, McNutt, Markey C., Park, Sahng Wook, Prather, Heidi B., Anderson, Norma N., Ho, Y.K., Hammer, Robert E., Horton, Jay D.
Publicado em 2006