Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the proteinase K subfamily of subtilases that reduces the number of LDL receptors (LDLRs) in liver through an undefined posttranscriptional mechanism. We show that purified PCSK9 added to the medium of HepG2 cells reduces the numbe...

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Autors principals: Lagace, Thomas A., Curtis, David E., Garuti, Rita, McNutt, Markey C., Park, Sahng Wook, Prather, Heidi B., Anderson, Norma N., Ho, Y.K., Hammer, Robert E., Horton, Jay D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1626117/
https://ncbi.nlm.nih.gov/pubmed/17080197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29383
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