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Redox Potential Control by Drug Binding to Cytochrome P450 3A4
The cytochrome P450s are ubiquitous heme proteins that utilize two reducing equivalents to cleave a ferrous iron - dioxygen complex to produce a single water molecule with the insertion of one oxygen atom into a bound substrate. For the case of soluble cytochrome P450 CYP101, it has been shown that...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2535932/ https://ncbi.nlm.nih.gov/pubmed/17948999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja074864x |
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