Mechanism of Drug-Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer

Using Nanodiscs, we quantitate the heterotropic interaction between two different drugs mediated by monomeric CYP3A4 incorporated into a native-like membrane environment. The mechanism of this interaction is deciphered by global analysis of multiple turnover experiments performed under identical con...

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Detaylı Bibliyografya
Yayımlandı:Biochemistry
Asıl Yazarlar: Denisov, Ilia G., Grinkova, Yelena V., Baylon, Javier L., Tajkhorshid, Emad, Sligar, Stephen G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757451/
https://ncbi.nlm.nih.gov/pubmed/25777547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00079
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