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Mechanism of Drug-Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer
Using Nanodiscs, we quantitate the heterotropic interaction between two different drugs mediated by monomeric CYP3A4 incorporated into a native-like membrane environment. The mechanism of this interaction is deciphered by global analysis of multiple turnover experiments performed under identical con...
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| Publicado en: | Biochemistry |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4757451/ https://ncbi.nlm.nih.gov/pubmed/25777547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00079 |
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