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Redox Potential Control by Drug Binding to Cytochrome P450 3A4

The cytochrome P450s are ubiquitous heme proteins that utilize two reducing equivalents to cleave a ferrous iron - dioxygen complex to produce a single water molecule with the insertion of one oxygen atom into a bound substrate. For the case of soluble cytochrome P450 CYP101, it has been shown that...

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Main Authors: Das, Aditi, Grinkova, Yelena V., Sligar, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2535932/
https://ncbi.nlm.nih.gov/pubmed/17948999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja074864x
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