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Synthesis of a Ring Expanded Bryostatin Analogue

A ring expanded bryostatin analogue was synthesized by utilizing a Ru-catalyzed tandem tetrahydropyran formation, a Pd-catalyzed tandem dihydropyran formation, and a ring-closing metathesis (RCM) as key steps. The analogue possesses potent anti-tumor activity against the NCI-ADR cancer cell line wit...

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Autori principali: Trost, Barry M., Yang, Hanbiao, Thiel, Oliver R., Frontier, Alison J., Brindle, Cheyenne S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533160/
https://ncbi.nlm.nih.gov/pubmed/17279751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja067305j
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