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Synthesis of a Ring Expanded Bryostatin Analogue
A ring expanded bryostatin analogue was synthesized by utilizing a Ru-catalyzed tandem tetrahydropyran formation, a Pd-catalyzed tandem dihydropyran formation, and a ring-closing metathesis (RCM) as key steps. The analogue possesses potent anti-tumor activity against the NCI-ADR cancer cell line wit...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2533160/ https://ncbi.nlm.nih.gov/pubmed/17279751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja067305j |
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