Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop Is Required for Interleukin (IL)-1-mediated Optimal NFκB and AP-1 Activation as Well as IL-6 Gene Expression

TAK1 (transforming growth factor-β-activated kinase 1), a mitogen-activated protein kinase kinase kinase, is activated by various cytokines, including interleukin-1 (IL-1). However, the precise regulation for TAK1 activation at the molecular level is still not fully understood. Here we report that d...

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Bibliographic Details
Main Authors: Yu, Yang, Ge, Ningling, Xie, Min, Sun, Wenjing, Burlingame, Susan, Pass, Amy K., Nuchtern, Jed G., Zhang, Dekai, Fu, Songbin, Schneider, Michael D., Fan, Jia, Yang, Jianhua
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528992/
https://ncbi.nlm.nih.gov/pubmed/18617512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802825200
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