Phosphorylation of Thr-516 and Ser-520 in the Kinase Activation Loop of MEKK3 Is Required for Lysophosphatidic Acid-mediated Optimal IκB Kinase β (IKKβ)/Nuclear Factor-κB (NF-κB) Activation

MEKK3 serves as a critical intermediate signaling molecule in lysophosphatidic acid-mediated nuclear factor-κB (NF-κB) activation. However, the precise regulation for MEKK3 activation at the molecular level is still not fully understood. Here we report the identification of two regulatory phosphoryl...

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Bibliographic Details
Main Authors: Sun, Wenjing, Ge, Ningling, Yu, Yang, Burlingame, Susan, Li, Xiaonan, Zhang, Ming, Ye, Shenglong, Fu, Songbin, Yang, Jianhua
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832941/
https://ncbi.nlm.nih.gov/pubmed/20068038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.051219
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