Phosphorylation of Thr-516 and Ser-520 in the Kinase Activation Loop of MEKK3 Is Required for Lysophosphatidic Acid-mediated Optimal IκB Kinase β (IKKβ)/Nuclear Factor-κB (NF-κB) Activation

MEKK3 serves as a critical intermediate signaling molecule in lysophosphatidic acid-mediated nuclear factor-κB (NF-κB) activation. However, the precise regulation for MEKK3 activation at the molecular level is still not fully understood. Here we report the identification of two regulatory phosphoryl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Sun, Wenjing, Ge, Ningling, Yu, Yang, Burlingame, Susan, Li, Xiaonan, Zhang, Ming, Ye, Shenglong, Fu, Songbin, Yang, Jianhua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832941/
https://ncbi.nlm.nih.gov/pubmed/20068038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.051219
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados