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Lesion Specificity in the Base Excision Repair Enzyme hNeil1: Modeling and Dynamics Studies

Base excision repair (BER) is the major pathway employed to excise oxidized DNA lesions. Human Neil1, a versatile glycosylase in the BER pathway, repairs a diverse array of oxidative lesions; however, the most prevalent 8-oxo-7, 8-dihydroguanine (8-oxoG) is only weakly excised. The structural origin...

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Bibliographic Details
Main Authors: Jia, Lei, Shafirovich, Vladimir, Geacintov, Nicholas E., Broyde, Suse
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527061/
https://ncbi.nlm.nih.gov/pubmed/17432829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi062269m
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