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Lesion Specificity in the Base Excision Repair Enzyme hNeil1: Modeling and Dynamics Studies
Base excision repair (BER) is the major pathway employed to excise oxidized DNA lesions. Human Neil1, a versatile glycosylase in the BER pathway, repairs a diverse array of oxidative lesions; however, the most prevalent 8-oxo-7, 8-dihydroguanine (8-oxoG) is only weakly excised. The structural origin...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527061/ https://ncbi.nlm.nih.gov/pubmed/17432829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi062269m |
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