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Mechanistic characterization of the HDV genomic ribozyme: The cleavage site base pair plays a structural role in facilitating catalysis

The hepatitis delta virus (HDV) ribozyme occurs in the genomic and antigenomic strands of the HDV RNA and within mammalian transcriptomes. Previous kinetic studies suggested that a wobble pair (G•U or A(+)•C) is preferred at the cleavage site; however, the reasons for this are unclear. We conducted...

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Bibliografische gegevens
Hoofdauteurs: Cerrone-Szakal, Andrea L., Chadalavada, Durga M., Golden, Barbara L., Bevilacqua, Philip C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525964/
https://ncbi.nlm.nih.gov/pubmed/18658121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1140308
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