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Mechanistic characterization of the HDV genomic ribozyme: The cleavage site base pair plays a structural role in facilitating catalysis
The hepatitis delta virus (HDV) ribozyme occurs in the genomic and antigenomic strands of the HDV RNA and within mammalian transcriptomes. Previous kinetic studies suggested that a wobble pair (G•U or A(+)•C) is preferred at the cleavage site; however, the reasons for this are unclear. We conducted...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2525964/ https://ncbi.nlm.nih.gov/pubmed/18658121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1140308 |
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