A Random shRNA-Encoding Library for Phenotypic Selection and Hit-Optimization

RNA interference (RNAi) is a mechanism for inhibiting gene expression through the action of small, non-coding RNAs. Most existing RNAi libraries target single genes through canonical pathways. Endogenous microRNAs (miRNAs), however, often target multiple genes and can act through non-canonical pathw...

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Bibliografiske detaljer
Main Authors: Wang, Yongping, Wang, Yun E., Cotticelli, M. Grazia, Wilson, Robert B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525836/
https://ncbi.nlm.nih.gov/pubmed/18779859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003171
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