Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis; the role of p53 and p21

Cucurbitacins have been shown to inhibit proliferation in a variety of cancer cell lines. The aim of this study was to determine their biological activity in colon cancer cell lines that do not harbor activated STAT3, the key target of cucurbitacin. In order to establish the role of activated kRas i...

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Autores principales: Escandell, José M., Kaler, Pawan, Recio, M. Carmen, Sasazuki, Takehiko, Shirasawa, Senji, Augenlicht, Leonard, Ríos, José-Luis, Klampfer, Lidija
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519804/
https://ncbi.nlm.nih.gov/pubmed/18561895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.05.004
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