Unusually Strong Binding to the DNA Minor Groove by a Highly Twisted Benzimidazole-Diphenylether: Induced Fit and Bound Water

RT29 is a dicationic diamidine derivative that does not obey the classical “rules” for shape and functional group placement that are expected to result in strong binding and specific recognition of the DNA minor groove. The compound contains a benzimidazole-diphenyl ether core that is flanked by the...

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Detalhes bibliográficos
Main Authors: Tanious, Farial A., Laine, William, Peixoto, Paul, Bailly, Christian, Goodwin, Kristie D., Lewis, Mark A., Long, Eric C., Georgiadis, Millie M., Tidwell, Richard R., Wilson, W. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519038/
https://ncbi.nlm.nih.gov/pubmed/17506529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi700288g
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