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Crystal structure of DNA-bound Co(III)·bleomycin B(2): Insights on intercalation and minor groove binding
Bleomycins constitute a widely studied class of complex DNA cleaving natural products that are used to treat various cancers. Since their first isolation, the bleomycins have provided a paradigm for the development and discovery of additional DNA-cleaving chemotherapeutic agents. The bleomycins cons...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2278181/ https://ncbi.nlm.nih.gov/pubmed/18362349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708143105 |
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