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DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication

Posttranslationally modified histones and DNA hypermethylation frequently interplay to deregulate gene expression in cancer. We report that acute myeloid leukemia (AML) with an aberrant histone methyltransferase, the mixed lineage leukemia partial tandem duplication (MLL-PTD), exhibits increased glo...

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Main Authors: Whitman, Susan P., Hackanson, Björn, Liyanarachchi, Sandya, Liu, Shujun, Rush, Laura J., Maharry, Kati, Margeson, Dean, Davuluri, Ramana, Wen, Jing, Witte, Tatiana, Yu, Li, Liu, Chunhui, Bloomfield, Clara D., Marcucci, Guido, Plass, Christoph, Caligiuri, Michael A.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518901/
https://ncbi.nlm.nih.gov/pubmed/18566324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-128595
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