DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication

Posttranslationally modified histones and DNA hypermethylation frequently interplay to deregulate gene expression in cancer. We report that acute myeloid leukemia (AML) with an aberrant histone methyltransferase, the mixed lineage leukemia partial tandem duplication (MLL-PTD), exhibits increased glo...

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Detalles Bibliográficos
Main Authors: Whitman, Susan P., Hackanson, Björn, Liyanarachchi, Sandya, Liu, Shujun, Rush, Laura J., Maharry, Kati, Margeson, Dean, Davuluri, Ramana, Wen, Jing, Witte, Tatiana, Yu, Li, Liu, Chunhui, Bloomfield, Clara D., Marcucci, Guido, Plass, Christoph, Caligiuri, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518901/
https://ncbi.nlm.nih.gov/pubmed/18566324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-128595
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