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Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth
Gene targeting experiments have shown that Delta-like 4 (Dll4) is a vascular-specific Notch ligand critical to normal vascular development. Recent studies have demonstrated that inhibition of Dll4/Notch signaling in tumor-bearing mice resulted in excessive, yet nonproductive tumor neovascularization...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2008
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518892/ https://ncbi.nlm.nih.gov/pubmed/18577711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-126045 |
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