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Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function
Delta-like 4 (Dll4), a membrane-bound ligand for Notch1 and Notch4, is selectively expressed in the developing endothelium and in some tumor endothelium, and it is induced by vascular endothelial growth factor (VEGF)-A and hypoxia. Gene targeting studies have shown that Dll4 is required for normal e...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
© 2006 by The American Society of Hematology
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895896/ https://ncbi.nlm.nih.gov/pubmed/16219802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1000 |
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