Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function

Delta-like 4 (Dll4), a membrane-bound ligand for Notch1 and Notch4, is selectively expressed in the developing endothelium and in some tumor endothelium, and it is induced by vascular endothelial growth factor (VEGF)-A and hypoxia. Gene targeting studies have shown that Dll4 is required for normal e...

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Main Authors: Williams, Cassin Kimmel, Li, Ji-Liang, Murga, Matilde, Harris, Adrian L., Tosato, Giovanna
Format: Artigo
Sprog:Inglês
Udgivet: © 2006 by The American Society of Hematology 2006
Fag:
Hemostasis, Thrombosis, and Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895896/
https://ncbi.nlm.nih.gov/pubmed/16219802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1000
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