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Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF(165) and semaphorin3A
Neuropilin-1 (NRP1) and NRP2 are cell surface receptors shared by class 3 semaphorins and vascular endothelial growth factor (VEGF). Ligand interaction with NRPs selects the specific signal transducer, plexins for semaphorins or VEGF receptors for VEGF, and promotes NRP internalization, which effect...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2288723/ https://ncbi.nlm.nih.gov/pubmed/18272814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-112474 |
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