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Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF(165) and semaphorin3A

Neuropilin-1 (NRP1) and NRP2 are cell surface receptors shared by class 3 semaphorins and vascular endothelial growth factor (VEGF). Ligand interaction with NRPs selects the specific signal transducer, plexins for semaphorins or VEGF receptors for VEGF, and promotes NRP internalization, which effect...

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Autores principales: Narazaki, Masashi, Segarra, Marta, Tosato, Giovanna
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288723/
https://ncbi.nlm.nih.gov/pubmed/18272814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-112474
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