Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth

Gene targeting experiments have shown that Delta-like 4 (Dll4) is a vascular-specific Notch ligand critical to normal vascular development. Recent studies have demonstrated that inhibition of Dll4/Notch signaling in tumor-bearing mice resulted in excessive, yet nonproductive tumor neovascularization...

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Main Authors: Segarra, Marta, Williams, Cassin Kimmel, la Luz Sierra, Maria de, Bernardo, Marcelino, McCormick, Peter J., Maric, Dragan, Regino, Celeste, Choyke, Peter, Tosato, Giovanna
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518892/
https://ncbi.nlm.nih.gov/pubmed/18577711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-126045
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