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Facile Detection of Acyl- and Peptidyl- intermediates on Thiotemplate Carrier Domains via Phosphopantetheinyl Elimination Reactions During Tandem Mass Spectrometry

With the emergence of drug resistance and the genomic revolution there has been a renewed interest in the genes that are responsible for the generation of bioactive natural products. Secondary metabolites of one major class are biosynthesized at one or more sites by ultra large enzymes that carry co...

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Библиографические подробности
Главные авторы: Dorrestein, Pieter C., Bumpus, Stefanie B., Calderone, Christopher T., Garneau-Tsodikova, Sylvie, Aron, Zachary D., Straight, Paul D., Kolter, Roberto, Walsh, Christopher T., Kelleher, Neil L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518290/
https://ncbi.nlm.nih.gov/pubmed/17042494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061169d
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