Activity Screening of Carrier Domains Within Non-Ribosomal Peptide Synthetases Using Complex Substrate Mixtures And Large Molecule Mass Spectrometry

For screening a pool of potential substrates that load carrier domains found in non-ribosomal peptide synthetases, large molecule mass spectrometry is shown to be an ideal, unbiased assay. Combining the high resolving power of Fourier-Transform Mass Spectrometry with the ability of adenylation domai...

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Bibliografiset tiedot
Päätekijät: Dorrestein, Pieter C., Blackhall, Jonathan, Straight, Paul D., Fischbach, Michael A., Garneau-Tsodikova, Sylvie, Edwards, Daniel L., McLaughlin, Shaun, Lin, Myat, Gerwick, William C., Kolter, Roberto, Walsh, Christopher T., Kelleher, Neil L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565507/
https://ncbi.nlm.nih.gov/pubmed/16460000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi052333k
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