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Convergence of isoprene and polyketide biosynthetic machinery: Isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis

The pksX gene cluster from Bacillus subtilis is predicted to encode the biosynthesis of an as yet uncharacterized hybrid nonribosomal peptide/polyketide secondary metabolite. We used a combination of biochemical and mass spectrometric techniques to assign functional roles to the proteins AcpK, PksC,...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Calderone, Christopher T., Kowtoniuk, Walter E., Kelleher, Neil L., Walsh, Christopher T., Dorrestein, Pieter C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482551/
https://ncbi.nlm.nih.gov/pubmed/16757561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603148103
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