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The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis

The ≈80-kb pksX gene cluster in Bacillus subtilis encodes an unusual hybrid polyketide/nonribosomal peptide synthase that has been linked to the production of the uncharacterized antibiotic bacillaene. Multiple copies of this synthase, each similar in size to the ribosome, assemble into a single org...

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Detalhes bibliográficos
Main Authors: Butcher, Rebecca A., Schroeder, Frank C., Fischbach, Michael A., Straight, Paul D., Kolter, Roberto, Walsh, Christopher T., Clardy, Jon
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785240/
https://ncbi.nlm.nih.gov/pubmed/17234808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610503104
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