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Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways

Mass spectrometry (MS) is an important tool for studying non-ribosomal peptide, polyketide, and fatty acid biosynthesis. Here we describe a new approach using multi-stage tandem MS on a common ion trap instrument to obtain high-resolution measurements of the masses of substrates and intermediates bo...

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Dettagli Bibliografici
Autori principali: Meluzzi, Dario, Zheng, Wei Hao, Hensler, Mary, Nizet, Victor, Dorrestein, Pieter C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519147/
https://ncbi.nlm.nih.gov/pubmed/18006314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.10.104
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