Dichlorination of a pyrrolyl-S-carrier protein by FADH(2)-dependent halogenase PltA during pyoluteorin biosynthesis

The antifungal natural product pyoluteorin contains a 4,5-dichloropyrrole moiety. The timing of dichlorination in the heteroaromatic ring is now shown to occur after proline is tethered by thioester linkage to the carrier protein PltL and enzymatically desaturated to the pyrrolyl-S-PltL. Surprisingl...

Full description

Saved in:
Bibliographic Details
Main Authors: Dorrestein, Pieter C., Yeh, Ellen, Garneau-Tsodikova, Sylvie, Kelleher, Neil L., Walsh, Christopher T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1236592/
https://ncbi.nlm.nih.gov/pubmed/16162666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506964102
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items