Unusual substrate and halide versatility of phenolic halogenase PltM

Controlled halogenation of chemically versatile substrates is difficult to achieve. Here we describe a unique flavin-dependent halogenase, PltM, which is capable of utilizing a wide range of halides for installation on a diverse array of phenolic compounds, including FDA-approved drugs and natural p...

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Udgivet i:Nat Commun
Main Authors: Mori, Shogo, Pang, Allan H., Thamban Chandrika, Nishad, Garneau-Tsodikova, Sylvie, Tsodikov, Oleg V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424973/
https://ncbi.nlm.nih.gov/pubmed/30890712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09215-9
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