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Processing of triplex-directed psoralen DNA interstrand crosslinks by recombination mechanisms
Gene targeting via homologous recombination (HR) is an important application in biotechnology and medicine. However, in mammalian cells HR is much less efficient than random integration. Triplex-forming oligonucleotides (TFOs) linked to DNA damaging agents (e.g. psoralen) can stimulate HR, providing...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2504320/ https://ncbi.nlm.nih.gov/pubmed/18628293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn438 |
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