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Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks

Psoralen is a chemotherapeutic agent that acts by producing DNA interstrand crosslinks (ICLs), which are especially cytotoxic and mutagenic because their complex chemical nature makes them difficult to repair. Proteins from multiple repair pathways, including nucleotide excision repair (NER), are in...

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Detalhes bibliográficos
Main Authors: Lange, Sabine S., Reddy, Madhava C., Vasquez, Karen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700216/
https://ncbi.nlm.nih.gov/pubmed/19446504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.04.001
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