Efficient processing of TFO-directed psoralen DNA interstrand crosslinks by the UvrABC nuclease

Photoreactive psoralens can form interstrand crosslinks (ICLs) in double-stranded DNA. In eubacteria, the endonuclease UvrABC plays a key role in processing psoralen ICLs. Psoralen-modified triplex-forming oligonucleotides (TFOs) can be used to direct ICLs to specific genomic sites. Previous studies...

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Bibliographic Details
Main Authors: Christensen, Laura A., Wang, Hong, Van Houten, Bennett, Vasquez, Karen M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602775/
https://ncbi.nlm.nih.gov/pubmed/18996898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn880
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