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Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics

Fatty acid amide hydrolase (FAAH) degrades neuromodulating fatty acid amides including anandamide (endogenous cannabinoid agonist) and oleamide (sleep-inducing lipid) at their sites of action and is intimately involved in their regulation. Herein we report the discovery of a potent, selective, and e...

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Главные авторы: Boger, Dale L., Miyauchi, Hiroshi, Du, Wu, Hardouin, Christophe, Fecik, Robert A., Cheng, Heng, Hwang, Inkyu, Hedrick, Michael P., Leung, Donmienne, Acevedo, Orlando, Guimarães, Cristiano R. W., Jorgensen, William L., Cravatt, Benjamin F.
Формат: Artigo
Язык:Inglês
Опубликовано: 2005
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492884/
https://ncbi.nlm.nih.gov/pubmed/15771430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm049614v
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