Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics

Fatty acid amide hydrolase (FAAH) degrades neuromodulating fatty acid amides including anandamide (endogenous cannabinoid agonist) and oleamide (sleep-inducing lipid) at their sites of action and is intimately involved in their regulation. Herein we report the discovery of a potent, selective, and e...

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Autores principales: Boger, Dale L., Miyauchi, Hiroshi, Du, Wu, Hardouin, Christophe, Fecik, Robert A., Cheng, Heng, Hwang, Inkyu, Hedrick, Michael P., Leung, Donmienne, Acevedo, Orlando, Guimarães, Cristiano R. W., Jorgensen, William L., Cravatt, Benjamin F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492884/
https://ncbi.nlm.nih.gov/pubmed/15771430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm049614v
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