Nuclear HuR accumulation through phosphorylation by Cdk1

A predominantly nuclear RNA-binding protein, HuR translocates to the cytoplasm in response to stress and proliferative signals, where it stabilizes or modulates the translation of target mRNAs. Here, we present evidence that HuR phosphorylation at S202 by the G2-phase kinase Cdk1 influences its subc...

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Detalhes bibliográficos
Main Authors: Kim, Hyeon Ho, Abdelmohsen, Kotb, Lal, Ashish, Pullmann, Rudolf, Yang, Xiaoling, Galban, Stefanie, Srikantan, Subramanya, Martindale, Jennifer L., Blethrow, Justin, Shokat, Kevan M., Gorospe, Myriam
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492667/
https://ncbi.nlm.nih.gov/pubmed/18593881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1645808
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