Ubiquitin-mediated proteolysis of HuR by heat shock

The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins. Although its post-transcriptional influence has been linked primarily to its cytoplasmic translocation, here we report that moderate heat shock (HS) potently red...

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Hauptverfasser: Abdelmohsen, Kotb, Srikantan, Subramanya, Yang, Xiaoling, Lal, Ashish, Kim, Hyeon Ho, Kuwano, Yuki, Galban, Stefanie, Becker, Kevin G, Kamara, Davida, de Cabo, Rafael, Gorospe, Myriam
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683047/
https://ncbi.nlm.nih.gov/pubmed/19322201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.67
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