Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs

In response to stress conditions, many mammalian mRNAs accumulate in stress granules (SGs) together with numerous RNA-binding proteins that control mRNA turnover and translation. However, the signaling cascades that modulate the presence of ribonucleoprotein (RNP) complexes in SGs are poorly underst...

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Bibliographic Details
Main Authors: Yoon, Je-Hyun, Abdelmohsen, Kotb, Srikantan, Subramanya, Guo, Rong, Yang, Xiaoling, Martindale, Jennifer L., Gorospe, Myriam
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902907/
https://ncbi.nlm.nih.gov/pubmed/24106086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt903
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