Phosphorylation of HuR by Chk2 regulates SIRT1 expression

The RNA-binding protein HuR regulates the stability of many target mRNAs. Here, we report that HuR associated with the 3'-untranslated region of the mRNA encoding the longevity and stress-response protein SIRT1, stabilized the SIRT1 mRNA, and increased SIRT1 expression levels. Unexpectedly, oxi...

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Hlavní autoři: Abdelmohsen, Kotb, Pullmann, Rudolf, Lal, Ashish, Kim, Hyeon Ho, Galban, Stefanie, Yang, Xiaoling, Blethrow, Justin, Walker, Mark, Shubert, Jonathan, Gillespie, David A., Furneaux, Henry, Gorospe, Myriam
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1986740/
https://ncbi.nlm.nih.gov/pubmed/17317627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.01.011
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