A γ-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains

In prion-infected mice, both the Notch-1 intracellular domain transcription factor (NICD) and the disease-causing prion protein (PrP(Sc)) increase in the brain preceding dendritic atrophy and loss. Because the drug LY411575 inhibits the γ-secretase-catalyzed cleavage of Notch-1 that produces NICD, w...

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Bibliografiske detaljer
Main Authors: Spilman, Patricia, Lessard, Pierre, Sattavat, Mamta, Bush, Clarissa, Tousseyn, Thomas, Huang, Eric J., Giles, Kurt, Golde, Todd, Das, Pritam, Fauq, Abdul, Prusiner, Stanley B., DeArmond, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492499/
https://ncbi.nlm.nih.gov/pubmed/18647832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803671105
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