Conserved properties of human and bovine prion strains on transmission to guinea pigs

The first transmissions of human prion diseases to rodents used guinea pigs (Gps, Cavia porcellus). Later, transgenic (Tg) mice expressing human or chimeric human/mouse PrP replaced Gps, but the small size of the mouse limits some investigations. To investigate the fidelity of strain-specific prion...

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Main Authors: Safar, Jiri G., Giles, Kurt, Lessard, Pierre, Letessier, Frederic, Patel, Smita, Serban, Ana, DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164925/
https://ncbi.nlm.nih.gov/pubmed/21727894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2011.89
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