Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis

BACKGROUND: Lung fibrosis is a devastating pulmonary disorder characterized by alveolar epithelial injury, extracellular matrix deposition and scar tissue formation. Due to its potent collagenolytic activity, cathepsin K, a lysosomal cysteine protease is an interesting target molecule with therapeut...

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Autors principals: Srivastava, Mrigank, Steinwede, Kathrin, Kiviranta, Riku, Morko, Jukka, Hoymann, Heinz-Gerd, Länger, Florian, Buhling, Frank, Welte, Tobias, Maus, Ulrich A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490691/
https://ncbi.nlm.nih.gov/pubmed/18638383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-9-54
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