Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis

BACKGROUND: Lung fibrosis is a devastating pulmonary disorder characterized by alveolar epithelial injury, extracellular matrix deposition and scar tissue formation. Due to its potent collagenolytic activity, cathepsin K, a lysosomal cysteine protease is an interesting target molecule with therapeut...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Srivastava, Mrigank, Steinwede, Kathrin, Kiviranta, Riku, Morko, Jukka, Hoymann, Heinz-Gerd, Länger, Florian, Buhling, Frank, Welte, Tobias, Maus, Ulrich A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490691/
https://ncbi.nlm.nih.gov/pubmed/18638383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-9-54
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky