Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a vital role in the resorption and remodeling of bone. Pycnodysostosis is a rare inherited osteochondrodysplasia that is caused by mutations of the cathepsin-K gene, charac...

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Autors principals: Saftig, Paul, Hunziker, Ernst, Wehmeyer, Olaf, Jones, Sheila, Boyde, Alan, Rommerskirch, Winfried, Moritz, Jörg Detlev, Schu, Peter, von Figura, Kurt
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC24840/
https://ncbi.nlm.nih.gov/pubmed/9811821
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