Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a vital role in the resorption and remodeling of bone. Pycnodysostosis is a rare inherited osteochondrodysplasia that is caused by mutations of the cathepsin-K gene, charac...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24840/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811821/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.23.13453 |
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